Washout Appearance in Gd-EOB-DTPA-Enhanced MR Imaging: A Differentiating Feature Between Hepatocellular Carcinoma With Paradoxical Uptake on the Hepatobiliary Phase and Focal Nodular Hyperplasia-Like Nodules
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong Woo | - |
dc.contributor.author | Lee, Chang Hee | - |
dc.contributor.author | Kim, Soo Byn | - |
dc.contributor.author | Park, Bit Na | - |
dc.contributor.author | Park, Yang Shin | - |
dc.contributor.author | Lee, Jongmee | - |
dc.contributor.author | Park, Cheol Min | - |
dc.date.accessioned | 2021-09-03T05:37:38Z | - |
dc.date.available | 2021-09-03T05:37:38Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83298 | - |
dc.description.abstract | Purpose To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. Materials and Methods This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), T2 scar, EOB scar, and chemical shift on in- and out-of-phase images. Multivariate logistic regression analysis was performed to assess MRI features for prediction of HCCpara. Results Compared with FNH-like nodules, HCCpara had significantly more frequent heterogeneous T1 SI (P < 0.0001), T2 hyperintensity (P=0.032), heterogeneous arterial enhancement (P<0.0001), washout appearance on the PVP and/or TP (P < 0.0001), heterogeneous uptake on the HBP (P < 0.0001), absence of EOB scar (P < 0.0001), and hyperintensity on DWI (P = 0.004). Multivariate logistic regression analysis revealed washout appearance as the only independent imaging feature associated with HCCpara (odds ratio, 7.019; P=0.042). Washout appearance also showed the best diagnostic performance with a sensitivity of 90% and a specificity of 100%. Conclusion Washout appearance on the PVP and/or TP is the most reliable imaging feature for differentiating HCCpara from FNH-like nodules. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ALCOHOLIC LIVER-CIRRHOSIS | - |
dc.subject | SIGNAL INTENSITY | - |
dc.subject | PATHOLOGICAL CORRELATION | - |
dc.subject | HEPATIC HEMANGIOMA | - |
dc.subject | LESIONS | - |
dc.subject | IMAGES | - |
dc.subject | AGENTS | - |
dc.subject | AREAS | - |
dc.title | Washout Appearance in Gd-EOB-DTPA-Enhanced MR Imaging: A Differentiating Feature Between Hepatocellular Carcinoma With Paradoxical Uptake on the Hepatobiliary Phase and Focal Nodular Hyperplasia-Like Nodules | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Chang Hee | - |
dc.contributor.affiliatedAuthor | Park, Yang Shin | - |
dc.contributor.affiliatedAuthor | Lee, Jongmee | - |
dc.contributor.affiliatedAuthor | Park, Cheol Min | - |
dc.identifier.doi | 10.1002/jmri.25493 | - |
dc.identifier.scopusid | 2-s2.0-84991070858 | - |
dc.identifier.wosid | 000401259900004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, v.45, no.6, pp.1599 - 1608 | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.citation.title | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.citation.volume | 45 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1599 | - |
dc.citation.endPage | 1608 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ALCOHOLIC LIVER-CIRRHOSIS | - |
dc.subject.keywordPlus | SIGNAL INTENSITY | - |
dc.subject.keywordPlus | PATHOLOGICAL CORRELATION | - |
dc.subject.keywordPlus | HEPATIC HEMANGIOMA | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | IMAGES | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | AREAS | - |
dc.subject.keywordAuthor | FNH like nodule | - |
dc.subject.keywordAuthor | gadoxetic acid | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | washout | - |
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