Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Washout Appearance in Gd-EOB-DTPA-Enhanced MR Imaging: A Differentiating Feature Between Hepatocellular Carcinoma With Paradoxical Uptake on the Hepatobiliary Phase and Focal Nodular Hyperplasia-Like Nodules

Authors
Kim, Jeong WooLee, Chang HeeKim, Soo BynPark, Bit NaPark, Yang ShinLee, JongmeePark, Cheol Min
Issue Date
6월-2017
Publisher
WILEY
Keywords
FNH like nodule; gadoxetic acid; hepatocellular carcinoma; magnetic resonance imaging; washout
Citation
JOURNAL OF MAGNETIC RESONANCE IMAGING, v.45, no.6, pp.1599 - 1608
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume
45
Number
6
Start Page
1599
End Page
1608
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83298
DOI
10.1002/jmri.25493
ISSN
1053-1807
Abstract
Purpose To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. Materials and Methods This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), T2 scar, EOB scar, and chemical shift on in- and out-of-phase images. Multivariate logistic regression analysis was performed to assess MRI features for prediction of HCCpara. Results Compared with FNH-like nodules, HCCpara had significantly more frequent heterogeneous T1 SI (P < 0.0001), T2 hyperintensity (P=0.032), heterogeneous arterial enhancement (P<0.0001), washout appearance on the PVP and/or TP (P < 0.0001), heterogeneous uptake on the HBP (P < 0.0001), absence of EOB scar (P < 0.0001), and hyperintensity on DWI (P = 0.004). Multivariate logistic regression analysis revealed washout appearance as the only independent imaging feature associated with HCCpara (odds ratio, 7.019; P=0.042). Washout appearance also showed the best diagnostic performance with a sensitivity of 90% and a specificity of 100%. Conclusion Washout appearance on the PVP and/or TP is the most reliable imaging feature for differentiating HCCpara from FNH-like nodules.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Jong mee photo

Lee, Jong mee
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE