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Antiviral Activities of Trichothecenes Isolated from Trichoderma albolutescens against Pepper Mottle Virus
- Authors
- Ryu, Seung Mok; Lee, Hae Min; Song, Eun Gyeong; Seo, Young Hye; Lee, Jun; Guo, Yuanqiang; Kim, Beom Seok; Kim, Jae-Jin; Hong, Jin Sung; Ryu, Ki Hyun; Lee, Dongho
- Issue Date
- 31-May-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Trichoderma albolutescens; trichothecene; vibrational circular dicbroism; Nicotiana benthamiana; Capsicum annuum; pepper mottle virus; antiviral agent
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.65, no.21, pp.4273 - 4279
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 65
- Number
- 21
- Start Page
- 4273
- End Page
- 4279
- ISSN
- 0021-8561
- Abstract
- A bioassay-guided isolation using a green fluorescence protein (GFP)-tagged pepper mottle virus (PepMoV-GFP) based leaf-disk method to obtain new antiviral agents led to the isolation of trichodermin, 1, and a new compound trichoderminol, 2, from EtOAc extract of Trichodettna albolutescens culture medium. The structures of compounds 1 and 2 were determined by MS and NMR experiments, and the absolute configurations of the compounds were established by experimental and calculated vibrational circular dichroism spectra Compounds 1 and 2 were evaluated for their anti-PepMoV potential in systemic host plants, such as tobacco and pepper, by :PepMoV-GFP based systemic host method. All compounds exhibited inactivation effects against PepMoV. Furthermore, compound 1 showed protective effects against PepMoV.
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Related Researcher
- Kim, Jae Jin
- College of Life Sciences and Biotechnology (Division of Environmental Science and Ecological Engineering)