Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness
DC Field | Value | Language |
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dc.contributor.author | Amidfar, Meysam | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Colic, Lejla | - |
dc.contributor.author | Arbabi, Mohammad | - |
dc.contributor.author | Mobaraki, Gholamhossein | - |
dc.contributor.author | Hassanzadeh, Gholamreza | - |
dc.contributor.author | Walter, Martin | - |
dc.date.accessioned | 2021-09-03T06:48:40Z | - |
dc.date.available | 2021-09-03T06:48:40Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 0803-9488 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83630 | - |
dc.description.abstract | Background: Neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-HT2A and 5-HT3A serotonin receptors in the pathophysiology of major depression.Aim: The aim of this study was to measure the relative expression of 5-HT2A and 5-HT3A receptor mRNA in peripheral blood mononuclear cells (PBMCs) of patients with major depressive disorder (MDD).Method: 5-HT2A and 5-HT3A receptor mRNA expressions were examined in PBMCs of 25 medication-naive-patients with MDD, 25 medication-free MDD patients, and 25 healthy controls. 5-HT2A and 5-HT3A receptor mRNA expressions were measured using real-time quantitative PCR. This study evaluated patients' clinical symptoms using the Hamilton Depression Rating Scale-17 items (HDRS) and the Beck Depression Inventory (BDI).Results: Relative 5-HTR2A mRNA expression was significantly higher in PBMCs of all MDD patients when compared with healthy controls (Z = -3.875, p<0.05). However, there was no significant difference in the relative levels of 5-HTR3A mRNA expression in PBMCs of all MDD patients when compared with healthy controls (Z = -1.328, p>0.05). MDD patients showed significant correlations between 5-HTR2A mRNA expression and HDRS scores (rs=0.902, p<0.001) and BDI scores (rs=0.878, p<0.001).Conclusion: This study showed that depressed patients, irrespective of treatment, have higher 5-HTR2A mRNA levels in PBMCs than healthy subjects. It also provided evidence that 5-HTR2A mRNA levels in PBMCs of MDD patients could be associated with the severity of depression and the duration of the illness. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | SUICIDE VICTIMS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | EMOTIONAL BRAIN | - |
dc.subject | 5-HT2 RECEPTORS | - |
dc.subject | BINDING-SITES | - |
dc.subject | SEROTONIN | - |
dc.subject | SYSTEM | - |
dc.subject | INFLAMMATION | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | ACTIVATION | - |
dc.title | Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1080/08039488.2016.1276624 | - |
dc.identifier.scopusid | 2-s2.0-85010669567 | - |
dc.identifier.wosid | 000399740500007 | - |
dc.identifier.bibliographicCitation | NORDIC JOURNAL OF PSYCHIATRY, v.71, no.4, pp.282 - 288 | - |
dc.relation.isPartOf | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.citation.title | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.citation.volume | 71 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 282 | - |
dc.citation.endPage | 288 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | SUICIDE VICTIMS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | EMOTIONAL BRAIN | - |
dc.subject.keywordPlus | 5-HT2 RECEPTORS | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Major depression | - |
dc.subject.keywordAuthor | 5-HT2A receptor | - |
dc.subject.keywordAuthor | 5-HT3A receptor | - |
dc.subject.keywordAuthor | mRNA expression | - |
dc.subject.keywordAuthor | PBMCs | - |
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