Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness
- Authors
- Amidfar, Meysam; Kim, Yong-Ku; Colic, Lejla; Arbabi, Mohammad; Mobaraki, Gholamhossein; Hassanzadeh, Gholamreza; Walter, Martin
- Issue Date
- 5월-2017
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Major depression; 5-HT2A receptor; 5-HT3A receptor; mRNA expression; PBMCs
- Citation
- NORDIC JOURNAL OF PSYCHIATRY, v.71, no.4, pp.282 - 288
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- NORDIC JOURNAL OF PSYCHIATRY
- Volume
- 71
- Number
- 4
- Start Page
- 282
- End Page
- 288
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83630
- DOI
- 10.1080/08039488.2016.1276624
- ISSN
- 0803-9488
- Abstract
- Background: Neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-HT2A and 5-HT3A serotonin receptors in the pathophysiology of major depression.Aim: The aim of this study was to measure the relative expression of 5-HT2A and 5-HT3A receptor mRNA in peripheral blood mononuclear cells (PBMCs) of patients with major depressive disorder (MDD).Method: 5-HT2A and 5-HT3A receptor mRNA expressions were examined in PBMCs of 25 medication-naive-patients with MDD, 25 medication-free MDD patients, and 25 healthy controls. 5-HT2A and 5-HT3A receptor mRNA expressions were measured using real-time quantitative PCR. This study evaluated patients' clinical symptoms using the Hamilton Depression Rating Scale-17 items (HDRS) and the Beck Depression Inventory (BDI).Results: Relative 5-HTR2A mRNA expression was significantly higher in PBMCs of all MDD patients when compared with healthy controls (Z = -3.875, p<0.05). However, there was no significant difference in the relative levels of 5-HTR3A mRNA expression in PBMCs of all MDD patients when compared with healthy controls (Z = -1.328, p>0.05). MDD patients showed significant correlations between 5-HTR2A mRNA expression and HDRS scores (rs=0.902, p<0.001) and BDI scores (rs=0.878, p<0.001).Conclusion: This study showed that depressed patients, irrespective of treatment, have higher 5-HTR2A mRNA levels in PBMCs than healthy subjects. It also provided evidence that 5-HTR2A mRNA levels in PBMCs of MDD patients could be associated with the severity of depression and the duration of the illness.
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