Protocatechuic Acid Enhances Osteogenesis, but Inhibits Adipogenesis in C3H10T1/2 and 3T3-L1 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rivera-Piza, Adriana | - |
dc.contributor.author | An, Young Jae | - |
dc.contributor.author | Kim, Do Kyung | - |
dc.contributor.author | Lee, Sung-Hyen | - |
dc.contributor.author | Kim, Jung-Bong | - |
dc.contributor.author | Choi, Jung-Sook | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.accessioned | 2021-09-03T08:50:22Z | - |
dc.date.available | 2021-09-03T08:50:22Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84236 | - |
dc.description.abstract | Abnormal activation of adipogenesis in mesenchymal stem cells (MSCs) and preadipocyte cells is associated with human metabolic disorders, such as osteoporosis and obesity. This study investigated the biological effects of protocatechuic acid (PCA) on the modulation of osteogenesis and adipogenesis in cultured cells. PCA stimulation of MSCs significantly increased intracellular mineralization during osteogenesis, but reduced lipid accumulation in both MSCs and 3T3-L1 preadipocyte cells during adipogenesis. Reverse transcription-polymerase chain reaction and immunoblotting analyses showed a dose-dependent upregulation of proosteogenic runt-related transcription factor 2 due to induction of b-catenin. PCA reduced the expression of proadipogenic transcription factor, peroxisome proliferator-activated receptor-c, and suppressed its promotor activity. These results suggest PCA exerts stimulatory effects on the osteogenesis of MSCs and inhibitory effects on the adipogenesis of MSCs and 3T3-L1 cells. PCA may contribute to maintain a coordinated metabolic balance between adipogenesis and osteogenesis, and thus may be useful for the prevention and alleviation of osteoporosis and obesity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | COLORIMETRIC ASSAY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | BLACK RICE | - |
dc.subject | ADIPOCYTE | - |
dc.subject | CYANIDIN | - |
dc.subject | OBESITY | - |
dc.subject | CYANIDIN-3-O-BETA-GLUCOSIDE | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | METABOLITE | - |
dc.title | Protocatechuic Acid Enhances Osteogenesis, but Inhibits Adipogenesis in C3H10T1/2 and 3T3-L1 Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.identifier.doi | 10.1089/jmf.2016.3833 | - |
dc.identifier.scopusid | 2-s2.0-85015614780 | - |
dc.identifier.wosid | 000397562100012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.20, no.3, pp.309 - 319 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 309 | - |
dc.citation.endPage | 319 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002206735 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | COLORIMETRIC ASSAY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BLACK RICE | - |
dc.subject.keywordPlus | ADIPOCYTE | - |
dc.subject.keywordPlus | CYANIDIN | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CYANIDIN-3-O-BETA-GLUCOSIDE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | METABOLITE | - |
dc.subject.keywordAuthor | protocatechuic acid | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.subject.keywordAuthor | RUNX2 | - |
dc.subject.keywordAuthor | osteogenesis | - |
dc.subject.keywordAuthor | adipogenesis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.