A Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye
- Authors
- Park, Yuli; Song, Jong Suk; Choi, Chul Young; Yoon, Kyung Chul; Lee, Hyung Keun; Kim, Hyun Seung
- Issue Date
- 3월-2017
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- dry eye syndrome; 0.1% sodium hyaluronate; 0.15% sodium hyaluronate; 0.3% sodium hyaluronate; 0.05% cyclosporine
- Citation
- JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, v.33, no.2, pp.66 - 72
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Volume
- 33
- Number
- 2
- Start Page
- 66
- End Page
- 72
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/84323
- DOI
- 10.1089/jop.2016.0086
- ISSN
- 1080-7683
- Abstract
- Purpose: To investigate the efficacy of 0.1%, 0.15%, and 0.3% sodium hyaluronate (SH) artificial tears compared with 0.05% cyclosporine (CS) ophthalmic solution for the treatment of dry eye. Methods: One hundred seventy-six patients were recruited and randomized to receive of 0.1%, 0.15%, and 0.3% SH and 0.05% CS. There was a primary end point which is the changes in the fluorescein corneal staining (FCS) score to determine noninferiority of 0.1%, 0.15%, and 0.3% SH. Secondary objective end points were lissamine green conjunctival staining (LGCS) scores, Schirmer test, and tear film break-up time (TBUT). Secondary subjective end point was ocular surface disease index (OSDI) score. These were evaluated before treatment and 6 and 12 weeks after start of treatment. Results: In the primary analysis, the mean change from baseline in FCS scores verified noninferiority of 0.1% and 0.15% SH to 0.05% CS and also indicated significant improvement of all groups (P < 0.05). Values for TBUT, LGCS scores, and OSDI scores showed significant improvements in all groups (P < 0.05), although no significant intergroup difference was shown. However, Schirmer test scores in the 0.15% SH group showed a significant tendency for better improvement at week 12 compared with the other groups (P < 0.05). No serious adverse events were observed. Conclusions: Administration of 0.1%, 0.15%, and 0.3% SH was effective in improving both the objective signs and subjective symptoms of dry eye. Those findings, in addition to the well-tolerated profile of 0.1%, 0.15%, and 0.3% SH, show that it is effective therapeutic method for dry eye.
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