Ten-day sequential versus triple therapy for Helicobacter pylori eradication: A prospective, open-label, randomized trial
- Authors
- Jung, Young Kul; Jung, Young Kul
- Issue Date
- 11월-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- antibiotics resistance; clarithromycin; Helicobacter pylori; metronidazole; peptic ulcer disease
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.27, no.11, pp.1675 - 1680
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 27
- Number
- 11
- Start Page
- 1675
- End Page
- 1680
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/84531
- DOI
- 10.1111/j.1440-1746.2012.07249.x
- ISSN
- 0815-9319
- Abstract
- Background and Aim Increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new first-line treatments for H. pylori. We have prospectively evaluated 10-day sequential versus conventional triple therapy in peptic ulcer patients. Methods One hundred and fifty-nine patients with peptic ulcer diseases were prospectively randomized to receive 10 days of lansoprazole, amoxicillin, and clarithromycin (conventional triple therapy) or 5 days of lansoprazole and amoxicillin followed by 5 days of lansoprazole, clarithromycin, and metronidazole (sequential therapy). Post-treatment H. pylori status was determined by the C-13-urea breath test. Eradication rates, antibiotic resistance rates by agar dilution method, drug compliance, and side-effects were compared. Results The intention-to-treat eradication rates were 75.9% (95% CI 66.585.3%, 60/79) in the sequential therapy group and 58.7% (95% CI 47.969.5%, 47/80) in the conventional triple therapy group (P = 0.01), while the per-protocol eradication rates were 86.8% (95% CI 78.794.8%, 59/68) and 67.6% (95% CI 56.578.7%, 46/68) (P = 0.01), respectively. Compliance and side-effects were similar in the two groups. Culture of H. pylori showed that 18.2% were resistant to clarithromycin, 41.9% to metronidazole. D
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.