RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Wei, Jun-Dong | - |
dc.contributor.author | Jang, Jae-Hyun | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-03T10:43:10Z | - |
dc.date.available | 2021-09-03T10:43:10Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01-29 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84864 | - |
dc.description.abstract | RanBPM is a scaffolding protein that regulates several cellular processes by interacting with various proteins. Previously, we reported that RanBPM acts as a negative regulator of BLT2, a low-affinity leukotriene B4 receptor; thus, it interferes with BLT2-mediated cell motility. In the present study, we observed that the expression levels of RanBPM were markedly reduced in the highly aggressive MDAMB- 435 and MDA-MB-231 human breast cancer cell lines compared with those in non-invasive MCF7 cells. Additionally, we found that the restoration of RanBPM levels suppressed the invasiveness of these aggressive breast cancer cells in a manner dependent on BLT2 activation. In contrast, the knockdown of endogenous RanBPM by shRNA strongly promoted invasiveness in non-invasive MCF-7 cells. We also observed that RanBPM suppressed the invasiveness of aggressive breast cancer cells by inhibiting BLT2mediated reactive oxygen species (ROS) generation and IL-8 production. Taken together, our results suggest that RanBPM acts as a negative regulator of BLT2, thus attenuating the invasiveness of aggressive breast cancer cells. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | BLT2-LINKED PATHWAY | - |
dc.subject | ANDROGEN RECEPTOR | - |
dc.subject | CARCINOMA CELLS | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | UP-REGULATION | - |
dc.subject | LUNG-CANCER | - |
dc.subject | IN-VITRO | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEIN | - |
dc.subject | INTERLEUKIN-8 | - |
dc.title | RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.1016/j.bbrc.2016.12.147 | - |
dc.identifier.scopusid | 2-s2.0-85009259968 | - |
dc.identifier.wosid | 000397259000048 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.483, no.1, pp.305 - 311 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 483 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 311 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | BLT2-LINKED PATHWAY | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR | - |
dc.subject.keywordPlus | CARCINOMA CELLS | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INTERLEUKIN-8 | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | BLT2 | - |
dc.subject.keywordAuthor | RanBPM | - |
dc.subject.keywordAuthor | Invasiveness | - |
dc.subject.keywordAuthor | IL-8 | - |
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