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Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper
- Authors
- Ryu, Seung Mok; Kwon, Jaeyoung; Seo, Young Hye; Song, Eun Gyeong; Hong, Seong Su; Kim, Beom Seok; Hong, Jin Sung; Ryu, Ki Hyun; Lee, Dongho
- Issue Date
- 2-1월-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Pepper mottle virus; Green fluorescent protein; Capsicum annuum; Brucea javanica; Quassinoid; Antiviral agent
- Citation
- VIRUS RESEARCH, v.227, pp.49 - 56
- Indexed
- SCIE
SCOPUS
- Journal Title
- VIRUS RESEARCH
- Volume
- 227
- Start Page
- 49
- End Page
- 56
- ISSN
- 0168-1702
- Abstract
- A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica. All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10 M. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40 M. (C) 2016 Elsevier B.V. All rights reserved.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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