Metabolic biomarkers for non-alcoholic fatty liver disease induced by high-fat diet: In vivo magnetic resonance spectroscopy of hyperpolarized [1-C-13] pyruvate
DC Field | Value | Language |
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dc.contributor.author | Moon, Chung-Man | - |
dc.contributor.author | Oh, Chang-Hyun | - |
dc.contributor.author | Ahn, Kyu-Youn | - |
dc.contributor.author | Yang, Jun-Seok | - |
dc.contributor.author | Kim, Jae-Young | - |
dc.contributor.author | Shin, Sang-Soo | - |
dc.contributor.author | Lim, Hyo-Soon | - |
dc.contributor.author | Heo, Sook-Hee | - |
dc.contributor.author | Seon, Hyun-Ju | - |
dc.contributor.author | Kim, Jin-Woong | - |
dc.contributor.author | Jeong, Gwang-Woo | - |
dc.date.accessioned | 2021-09-03T11:07:20Z | - |
dc.date.available | 2021-09-03T11:07:20Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84955 | - |
dc.description.abstract | Hyperpolarized C-13 magnetic resonance spectroscopy (MRS) to assess hepatic metabolism in nonalcoholic fatty liver disease (NAFLD) has not been reported. This study searched for cellular metabolism-based biomarkers for NAFLD induced by a high-fat diet (HFD) in rats. Also, correlations of the biomarkers with enzyme levels and histopathology were identified during a 6-week follow-up. Six rats were fed a control diet (CD) and seven rats were fed the HFD for 6 weeks. Hyperpolarized 13C dynamic MRS was performed on rat liver following an injection of hyperpolarized [1-C-13] pyruvate. Compared with CD-fed rats, HFD-fed rats showed significant increases in the levels of serum alanine aminotransferase and low-density lipoprotein cholesterol at weeks 4 and 6 of follow-up. After the 6 week HFD, the ratios of [1-C-13] alanine/pyruvate and [1-C-13] lactate/pyruvate were significantly increased, as were the levels of alanine aminotransferase and lactate dehydrogenase, which are potentially associated with hepatosteatosis. The results implicate [1-C-13] alanine and [1-C-13] lactate as potentially useful noninvasive biomarkers of hepatosteatosis occurring in NAFLD. (C) 2016 Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | RELAXATION-TIMES | - |
dc.subject | QUANTIFICATION | - |
dc.subject | MOUSE | - |
dc.subject | AMINOTRANSFERASE | - |
dc.subject | PATHOGENESIS | - |
dc.subject | STEATOSIS | - |
dc.subject | LACTATE | - |
dc.subject | ALANINE | - |
dc.subject | MODEL | - |
dc.title | Metabolic biomarkers for non-alcoholic fatty liver disease induced by high-fat diet: In vivo magnetic resonance spectroscopy of hyperpolarized [1-C-13] pyruvate | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Chang-Hyun | - |
dc.identifier.doi | 10.1016/j.bbrc.2016.08.118 | - |
dc.identifier.scopusid | 2-s2.0-85008256494 | - |
dc.identifier.wosid | 000392461600018 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.482, no.1, pp.112 - 119 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 482 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 112 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | RELAXATION-TIMES | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | AMINOTRANSFERASE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordPlus | LACTATE | - |
dc.subject.keywordPlus | ALANINE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Hyperpolarized C-13 | - |
dc.subject.keywordAuthor | Dynamic nuclear polarization (DNP) | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease (NAFLD) | - |
dc.subject.keywordAuthor | High-fat diet | - |
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