Aflatoxin B-1 Detoxification by Aspergillus oryzae from Meju, a Traditional Korean Fermented Soybean Starter
- Authors
- Lee, Kyu Ri; Yang, Sun Min; Cho, Sung Min; Kim, Myunghee; Hong, Sung-Yong; Chung, Soo Hyun
- Issue Date
- Jan-2017
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Aflatoxin B-1; biodegradation; detoxification; soybean fermentation starter
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.27, no.1, pp.57 - 66
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 1
- Start Page
- 57
- End Page
- 66
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/85158
- DOI
- 10.4014/jmb.1607.07064
- ISSN
- 1017-7825
- Abstract
- Aflatoxins are classified as Group 1 (carcinogenic to humans) by the International Agency for Research on Cancer. In this study, a total of 134 fungal strains were isolated from 65 meju samples, and two fungal isolates were selected as potential aflatoxin B-1 (AFB(1))biodetoxification fungi. These fungi were identified as Aspergillus oryzae MAO103 and A. oryzae MAO104 by sequencing the beta-tubulin gene. The two A. oryzae strains were able to degrade more than 90% of AFB(1) (initial concentration: 40 mu g/l) in a culture broth in 14 days. The mutagenic effects of AFB(1) treated with A. oryzae MAO103 and MAO104 significantly decreased to 5.7% and 6.4%, respectively, in the frame-shift mutation of Ames tests using Salmonella typhimurium TA98. The base-substituting mutagenicity of AFB(1) was also decreased by the two fungi. Moreover, AFB(1) production by Aspergillus flavus was significantly decreased by the two A. oryzae strains on soybean-based agar plates. Our data suggest that the two AFB-dteoxifying A. oryzae strains have potential application to control AFB(1) in foods and feeds.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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