Hypocalvaria of Newborn Infant: Intrauterine Exposure to an Angiotensin Receptor Blocker

Abstract

Angiotensin receptor blockers are contraindicated drugs during pregnancy because of their potential fetotoxicity, including oligohydramnios, anuria, renal tubular dysplasia, limb contractures, cranial ossification defects, prolonged patent ductus arteriosus, and even in utero death. It is believed that these abnormalities are associated with drug-mediated fetal hypotension. We report a case of skull ossification defects, pneumothorax, renal parenchymal disease, congenital calcaneovalgus foot, and inferior vena cava thrombosis in a neonate born to a hypertensive woman who had continued use of an angiotensin receptor blocker during her pregnancy.