Induced neural stem cells as a means of treatment in Huntington's disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Kyung-Ah | - |
dc.contributor.author | Hong, Sunghoi | - |
dc.date.accessioned | 2021-09-03T15:02:19Z | - |
dc.date.available | 2021-09-03T15:02:19Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1471-2598 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86324 | - |
dc.description.abstract | Introduction: Huntington's disease (HD) is an inherited neurodegenerative disease characterized by chorea, dementia, and depression caused by progressive nerve cell degeneration, which is triggered by expanded CAG repeats in the huntingtin (Htt) gene. Currently, there is no cure for this disease, nor is there an effective medicine available to delay or improve the physical, mental, and behavioral severities caused by it.Areas covered: In this review, the authors describe the use of induced neural stem cells (iNSCs) by direct conversion technology, which offers great advantages as a therapeutic cell type to treat HD.Expert opinion: Cell conversion of somatic cells into a desired stem cell type is one of the most promising treatments for HD because it could be facilitated for the generation of patient-specific neural stem cells. The induced pluripotent stem cells (iPSCs) have a powerful potential for differentiation into neurons, but they may cause teratoma formation due to an undifferentiated pluripotent stem cell after transplantation Therefore, direct conversion of somatic cells into iNSCs is a promising alternative technology in regenerative medicine and the iNSCs may be provided as a therapeutic cell source for Huntington's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | MARROW STROMAL CELLS | - |
dc.subject | ADULT HUMAN FIBROBLASTS | - |
dc.subject | DIRECT CONVERSION | - |
dc.subject | RAT MODEL | - |
dc.subject | MOUSE FIBROBLASTS | - |
dc.subject | PROGENITOR CELLS | - |
dc.subject | NEURONAL CELLS | - |
dc.subject | DOPAMINERGIC-NEURONS | - |
dc.subject | FUNCTIONAL RECOVERY | - |
dc.subject | MOLECULAR MEDICINE | - |
dc.title | Induced neural stem cells as a means of treatment in Huntington's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sunghoi | - |
dc.identifier.doi | 10.1080/14712598.2017.1365133 | - |
dc.identifier.scopusid | 2-s2.0-85030464784 | - |
dc.identifier.wosid | 000413961800002 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON BIOLOGICAL THERAPY, v.17, no.11, pp.1333 - 1343 | - |
dc.relation.isPartOf | EXPERT OPINION ON BIOLOGICAL THERAPY | - |
dc.citation.title | EXPERT OPINION ON BIOLOGICAL THERAPY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1333 | - |
dc.citation.endPage | 1343 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | ADULT HUMAN FIBROBLASTS | - |
dc.subject.keywordPlus | DIRECT CONVERSION | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | MOUSE FIBROBLASTS | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | NEURONAL CELLS | - |
dc.subject.keywordPlus | DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | FUNCTIONAL RECOVERY | - |
dc.subject.keywordPlus | MOLECULAR MEDICINE | - |
dc.subject.keywordAuthor | Induced neural stem cells | - |
dc.subject.keywordAuthor | Huntington&apos | - |
dc.subject.keywordAuthor | s diseases | - |
dc.subject.keywordAuthor | stem cell therapy | - |
dc.subject.keywordAuthor | cell conversion | - |
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