Induced neural stem cells as a means of treatment in Huntington's disease
- Authors
- Choi, Kyung-Ah; Hong, Sunghoi
- Issue Date
- 2017
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Induced neural stem cells; Huntington' s diseases; stem cell therapy; cell conversion
- Citation
- EXPERT OPINION ON BIOLOGICAL THERAPY, v.17, no.11, pp.1333 - 1343
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERT OPINION ON BIOLOGICAL THERAPY
- Volume
- 17
- Number
- 11
- Start Page
- 1333
- End Page
- 1343
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86324
- DOI
- 10.1080/14712598.2017.1365133
- ISSN
- 1471-2598
- Abstract
- Introduction: Huntington's disease (HD) is an inherited neurodegenerative disease characterized by chorea, dementia, and depression caused by progressive nerve cell degeneration, which is triggered by expanded CAG repeats in the huntingtin (Htt) gene. Currently, there is no cure for this disease, nor is there an effective medicine available to delay or improve the physical, mental, and behavioral severities caused by it.Areas covered: In this review, the authors describe the use of induced neural stem cells (iNSCs) by direct conversion technology, which offers great advantages as a therapeutic cell type to treat HD.Expert opinion: Cell conversion of somatic cells into a desired stem cell type is one of the most promising treatments for HD because it could be facilitated for the generation of patient-specific neural stem cells. The induced pluripotent stem cells (iPSCs) have a powerful potential for differentiation into neurons, but they may cause teratoma formation due to an undifferentiated pluripotent stem cell after transplantation Therefore, direct conversion of somatic cells into iNSCs is a promising alternative technology in regenerative medicine and the iNSCs may be provided as a therapeutic cell source for Huntington's disease.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.