Characteristics of Prostate Cancer by Opportunistic Screening in Korean Men with a Prostate-Specific Antigen Level Less Than 4.0 ng per Milliliter
- Authors
- Choi, Hoon; Cho, Seok; Bae, Jae Hyun; Lee, Sang Eun; Hong, Sung Kyu; Moon, Du Geon; Cheon, Jun; Byun, Seok-Soo; Park, Jae Young
- Issue Date
- 2017
- Publisher
- KARGER
- Keywords
- Biopsy; Prostate-specific antigen; Prostate cancer
- Citation
- UROLOGIA INTERNATIONALIS, v.99, no.2, pp.143 - 148
- Indexed
- SCIE
SCOPUS
- Journal Title
- UROLOGIA INTERNATIONALIS
- Volume
- 99
- Number
- 2
- Start Page
- 143
- End Page
- 148
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86393
- DOI
- 10.1159/000454886
- ISSN
- 0042-1138
- Abstract
- Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. Methods: A total of 1,680 men with PSA <= 4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. Results: PCa was diagnosed in 331 (19.6%) and 99 of these 331 cancers (14.9%) had a Gleason score of 7 or higher. The detection rate of PCa increased from 6.67% (<= 0.5 ng/mL) to 20.36% (3.01-3.9 ng/mL). There were significant differences in age 65.7 vs. 62.1 years, prostate volume 33.4 vs. 38.2 g, PSA density 0.10 vs. 0.08 ng/mL/mL between men with and without PCa. On multivariable analysis, age and prostate volume were the best independent discriminative parameters. When comparing PCa patients with a Gleason score less than 6 to those with a 7 or higher, patients with a Gleason score 7 or higher were older (67.2 vs. 64.8 years). Conclusions: Even when the PSA level is less than 4 ng/mL, PCas, including high-grade cancers, were detected in a significant number of men. In this group, patients with PCa were older and had a smaller prostate volume and high-grade cancers were detected more frequently in older cancer patients. (C) 2017 S. Karger AG, Basel
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