Selenium Administration Attenuates 5-Flurouracil-Induced Intestinal Mucositis
- Authors
- Lee, Jae Min; Chun, Hoon Jai; Choi, Hyuk Soon; Kim, Eun Sun; Seo, Yeon Seok; Jeen, Yoon Tae; Lee, Hong Sik; Um, Soon Ho; Kim, Chul Hwan; Sul, Donggeun
- Issue Date
- 2017
- Publisher
- ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
- Citation
- NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, v.69, no.4, pp.616 - 622
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Volume
- 69
- Number
- 4
- Start Page
- 616
- End Page
- 622
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86410
- DOI
- 10.1080/01635581.2017.1300289
- ISSN
- 0163-5581
- Abstract
- Chemotherapy-induced mucositis is mediated by the release of proinflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including the protection of membrane lipids and macromolecules against oxidative damage. However, to date, there is little evidence on the effect of trace elements on intestinal mucositis after chemotherapy. This study investigated the protective effect of selenium against chemotherapy-induced mucositis in rats. Twenty-four 9-wk-old female Wistar rats were randomized to 4 groups: control, selenium, 5-fluorouracil (5-FU), and 5-FU plus selenium. Mucositis was induced by a single dose of 5-FU (400mg/kg BW) via intraperitoneal injection, and selenium was administered by a single intraperitoneal dose of sodium selenite (0.2mg/kg BW). Diarrhea and weight loss after 5-FU administration were attenuated by selenium treatment. The mean villus height in the 5-FU plus selenium group was significantly taller than rats administered with 5-FU alone, but not significantly different compared to the control group. Interleukin (IL)-1 and tumor necrosis factor (TNF)- mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1, P < 0.01; TNF-, P < 0.05). These findings indicate that selenium protects the mucosa during chemotherapy via its anti-inflammatory effects and its suppression of cytotoxic cytokine production.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Medicine > 1. Journal Articles
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