Visualization of Macrophage Recruitment to Inflammation Lesions using Highly Sensitive and Stable Radionuclide-Embedded Gold Nanoparticles as a Nuclear Bio-Imaging Platform
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Bong | - |
dc.contributor.author | Lee, Ho Won | - |
dc.contributor.author | Singh, Thoudam Debraj | - |
dc.contributor.author | Li, Yinghua | - |
dc.contributor.author | Kim, Sang Kyoon | - |
dc.contributor.author | Cho, Sung Jin | - |
dc.contributor.author | Lee, Sang-Woo | - |
dc.contributor.author | Jeong, Shin Young | - |
dc.contributor.author | Ahn, Byeong-Cheol | - |
dc.contributor.author | Choi, Sangil | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Lim, Dong-Kwon | - |
dc.contributor.author | Lee, Jaetae | - |
dc.contributor.author | Jeon, Yong Hyun | - |
dc.date.accessioned | 2021-09-03T15:20:21Z | - |
dc.date.available | 2021-09-03T15:20:21Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1838-7640 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86428 | - |
dc.description.abstract | Reliable and sensitive imaging tools are required to track macrophage migration and provide a better understating of their biological roles in various diseases. Here, we demonstrate the possibility of radioactive iodide-embedded gold nanoparticles (RIe-AuNPs) as a cell tracker for nuclear medicine imaging. To demonstrate this utility, we monitored macrophage migration to carrageenan-induced sites of acute inflammation in living subjects and visualized the effects of anti-inflammatory agents on this process. Macrophage labeling with RIe-AuNPs did not alter their biological functions such as cell proliferation, phenotype marker expression, or phagocytic activity. In vivo imaging with positron-emission tomography revealed the migration of labeled macrophages to carrageenan-induced inflammation lesions 3 h after transfer, with highest recruitment at 6 h and a slight decline of radioactive signal at 24 h; these findings were highly consistent with the data of a bio-distribution study. Treatment with dexamethasone (an anti-inflammation drug) or GSK5182 (an ERR. inverse agonist) hindered macrophage recruitment to the inflamed sites. Our findings suggest that a cell tracking strategy utilizing RIe-AuNPs will likely be highly useful in research related to macrophage-related disease and cell-based therapies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IVYSPRING INT PUBL | - |
dc.subject | CANCER-IMMUNOTHERAPY | - |
dc.subject | INVERSE AGONIST | - |
dc.subject | CELL TRACKING | - |
dc.subject | PET | - |
dc.subject | INFECTION | - |
dc.subject | NANORODS | - |
dc.subject | MICE | - |
dc.subject | TRAFFICKING | - |
dc.subject | IODIDE | - |
dc.subject | MODEL | - |
dc.title | Visualization of Macrophage Recruitment to Inflammation Lesions using Highly Sensitive and Stable Radionuclide-Embedded Gold Nanoparticles as a Nuclear Bio-Imaging Platform | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong-Kwon | - |
dc.identifier.doi | 10.7150/thno.17131 | - |
dc.identifier.scopusid | 2-s2.0-85014488919 | - |
dc.identifier.wosid | 000396559600010 | - |
dc.identifier.bibliographicCitation | THERANOSTICS, v.7, no.4, pp.926 - 934 | - |
dc.relation.isPartOf | THERANOSTICS | - |
dc.citation.title | THERANOSTICS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 926 | - |
dc.citation.endPage | 934 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | CANCER-IMMUNOTHERAPY | - |
dc.subject.keywordPlus | INVERSE AGONIST | - |
dc.subject.keywordPlus | CELL TRACKING | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | NANORODS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | IODIDE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | nuclear bio-imaging platform | - |
dc.subject.keywordAuthor | macrophage migration | - |
dc.subject.keywordAuthor | acute inflammation | - |
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