VEGF overexpression predicts poor survival in hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Choi, Sae Byeol | - |
dc.contributor.author | Han, Hyung Joon | - |
dc.contributor.author | Kim, Wan Bae | - |
dc.contributor.author | Song, Tae Jin | - |
dc.contributor.author | Choi, Sang Yong | - |
dc.date.accessioned | 2021-09-03T15:24:05Z | - |
dc.date.available | 2021-09-03T15:24:05Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2391-5463 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86448 | - |
dc.description.abstract | Objective: The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection. Methods: 234 patients with HCC following surgical resection were enrolled. Clinicopathological and survival data were analyzed, and immunohistochemical staining was performed on tissue microarray sections using the anti-VEGF, anti-Akt, anti-HSP70, and anti-HSP27 antibodies. Results: The 3- and 5-year overall survival rates were 86.5 and 81.54%, respectively. Multivariate analysis revealed that VEGF expression (P = 0.017, HR = 2.573) and T stage (P < 0.001, HR = 4.953) were independent prognostic factors for overall survival. Immunohistochemical staining showed that the expression of Akt, HSP70, and HSP27 did not affect the overall survival rate. The 3- and 5-year disease-free survival rates were 58.2 and 49.4%, respectively. Compared to the VEGF(-)/(+) group, the VEGF(++)/ (+++) group demonstrated significantly higher proportion of patients with AFP levels > 400 ng/mL, capsule invasion, and microvascular invasion. Conclusion: VEGF overexpression was associated with capsule invasion, microvascular invasion, and a poor overall survival rate. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DE GRUYTER OPEN LTD | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | HEAT-SHOCK PROTEINS | - |
dc.subject | MICROVASCULAR INVASION | - |
dc.subject | CURATIVE RESECTION | - |
dc.subject | HEPATIC RESECTION | - |
dc.subject | CELL-DEATH | - |
dc.subject | EXPRESSION | - |
dc.subject | RECURRENCE | - |
dc.subject | PTEN | - |
dc.subject | CHAPERONES | - |
dc.title | VEGF overexpression predicts poor survival in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sae Byeol | - |
dc.contributor.affiliatedAuthor | Han, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Wan Bae | - |
dc.contributor.affiliatedAuthor | Song, Tae Jin | - |
dc.identifier.doi | 10.1515/med-2017-0061 | - |
dc.identifier.scopusid | 2-s2.0-85040358715 | - |
dc.identifier.wosid | 000417640400001 | - |
dc.identifier.bibliographicCitation | OPEN MEDICINE, v.12, no.1, pp.430 - 439 | - |
dc.relation.isPartOf | OPEN MEDICINE | - |
dc.citation.title | OPEN MEDICINE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 430 | - |
dc.citation.endPage | 439 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | HEAT-SHOCK PROTEINS | - |
dc.subject.keywordPlus | MICROVASCULAR INVASION | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | HEPATIC RESECTION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | PTEN | - |
dc.subject.keywordPlus | CHAPERONES | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | hepatic resection | - |
dc.subject.keywordAuthor | prognostic marker | - |
dc.subject.keywordAuthor | VEGF | - |
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