VEGF overexpression predicts poor survival in hepatocellular carcinoma
- Authors
- Choi, Sae Byeol; Han, Hyung Joon; Kim, Wan Bae; Song, Tae Jin; Choi, Sang Yong
- Issue Date
- 2017
- Publisher
- DE GRUYTER OPEN LTD
- Keywords
- Hepatocellular carcinoma; hepatic resection; prognostic marker; VEGF
- Citation
- OPEN MEDICINE, v.12, no.1, pp.430 - 439
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPEN MEDICINE
- Volume
- 12
- Number
- 1
- Start Page
- 430
- End Page
- 439
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86448
- DOI
- 10.1515/med-2017-0061
- ISSN
- 2391-5463
- Abstract
- Objective: The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection. Methods: 234 patients with HCC following surgical resection were enrolled. Clinicopathological and survival data were analyzed, and immunohistochemical staining was performed on tissue microarray sections using the anti-VEGF, anti-Akt, anti-HSP70, and anti-HSP27 antibodies. Results: The 3- and 5-year overall survival rates were 86.5 and 81.54%, respectively. Multivariate analysis revealed that VEGF expression (P = 0.017, HR = 2.573) and T stage (P < 0.001, HR = 4.953) were independent prognostic factors for overall survival. Immunohistochemical staining showed that the expression of Akt, HSP70, and HSP27 did not affect the overall survival rate. The 3- and 5-year disease-free survival rates were 58.2 and 49.4%, respectively. Compared to the VEGF(-)/(+) group, the VEGF(++)/ (+++) group demonstrated significantly higher proportion of patients with AFP levels > 400 ng/mL, capsule invasion, and microvascular invasion. Conclusion: VEGF overexpression was associated with capsule invasion, microvascular invasion, and a poor overall survival rate.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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