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Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius
- Authors
- Jin, Qinghao; Lee, Jin Woo; Jang, Hari; Choi, Ji Eun; Kim, Hyung Sik; Lee, Dongho; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 15-Dec-2016
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Echinops latifolius; Asteraceae; Anti-inflammatory; Dimeric sesquiterpene; Thiophene
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.24, pp.5995 - 5998
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 26
- Number
- 24
- Start Page
- 5995
- End Page
- 5998
- ISSN
- 0960-894X
- Abstract
- Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3-8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (H-1 and C-13 NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production. (C) 2016 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology