In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127
DC Field | Value | Language |
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dc.contributor.author | Cho, Young Chol | - |
dc.contributor.author | Pak, Pyo June | - |
dc.contributor.author | Joo, Yong Hoon | - |
dc.contributor.author | Lee, Hoi-Seon | - |
dc.contributor.author | Chung, Namhyun | - |
dc.date.accessioned | 2021-09-03T15:50:51Z | - |
dc.date.available | 2021-09-03T15:50:51Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86551 | - |
dc.description.abstract | Graphene oxide (GO) has been a focus of research in the fields of electronics, energy, and biomedicine, including drug delivery. Thus, single- and multi-layered GO (SLGO and MLGO) have been produced and investigated. However, little information on their toxicity and biocompatibility is available. In the present study, we performed a comprehensive study of the size-and dose-dependent toxicity of GOs in the presence or absence of Pluronic F-127 on THP-1 cells by examining their viability, membrane integrity, levels of cytokine and ROS production, phagocytosis, and cytometric apoptosis. Moreover, as an extended study, a toxicity evaluation in the acute and chronic phases was performed in mice via intravenous injection of the materials. GOs exhibited dose-and size-dependent toxicity. Interestingly, SLGO induced ROS production to a lesser extent than MLGO. Cytometric analysis indicated that SLGO induced necrosis and apoptosis to a lesser degree than MLGO. In addition, cell damage and IL-1 beta production were influenced by phagocytosis. A histological animal study revealed that GOs of various sizes induced acute and chronic damage to the lung and kidney in the presence or absence of Pluronic F-127. These results will facilitate studies of GO prior to its biomedical application. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | WALLED CARBON NANOTUBES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | ANTICANCER ACTIVITY | - |
dc.subject | INDUCE APOPTOSIS | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | CELLS | - |
dc.subject | MACROPHAGES | - |
dc.subject | NANOMATERIALS | - |
dc.subject | PROTEIN | - |
dc.subject | NANOPARTICLES | - |
dc.title | In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Namhyun | - |
dc.identifier.doi | 10.1038/srep38884 | - |
dc.identifier.scopusid | 2-s2.0-85006056300 | - |
dc.identifier.wosid | 000389656400001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | WALLED CARBON NANOTUBES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | INDUCE APOPTOSIS | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
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