The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Han-Joon | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-03T16:01:04Z | - |
dc.date.available | 2021-09-03T16:01:04Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0924-2708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86584 | - |
dc.description.abstract | Background: Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-gamma+ 874 A/T, TNF-alpha-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD. Method: This study enroled 135 PD patients and 135 healthy controls. INF-gamma+874 A/T (rs2430561), TNF-alpha-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped. Results: There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group. Conclusion: We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | MAJOR DEPRESSIVE DISORDER | - |
dc.subject | NEURODEGENERATION HYPOTHESIS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | GENETIC-POLYMORPHISM | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | IFN-GAMMA | - |
dc.subject | ASSOCIATION | - |
dc.subject | PROMOTER | - |
dc.subject | SPECTRUM | - |
dc.subject | CHINESE | - |
dc.title | The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1017/neu.2016.25 | - |
dc.identifier.scopusid | 2-s2.0-84976329003 | - |
dc.identifier.wosid | 000387823800008 | - |
dc.identifier.bibliographicCitation | ACTA NEUROPSYCHIATRICA, v.28, no.6, pp.357 - 361 | - |
dc.relation.isPartOf | ACTA NEUROPSYCHIATRICA | - |
dc.citation.title | ACTA NEUROPSYCHIATRICA | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 357 | - |
dc.citation.endPage | 361 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MAJOR DEPRESSIVE DISORDER | - |
dc.subject.keywordPlus | NEURODEGENERATION HYPOTHESIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | GENETIC-POLYMORPHISM | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | SPECTRUM | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | IFN-r | - |
dc.subject.keywordAuthor | IL-10 | - |
dc.subject.keywordAuthor | panic disorder | - |
dc.subject.keywordAuthor | TNF-alpha | - |
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