The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients
- Authors
- Kim, Han-Joon; Kim, Yong-Ku
- Issue Date
- 12월-2016
- Publisher
- CAMBRIDGE UNIV PRESS
- Keywords
- cytokine; IFN-r; IL-10; panic disorder; TNF-alpha
- Citation
- ACTA NEUROPSYCHIATRICA, v.28, no.6, pp.357 - 361
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA NEUROPSYCHIATRICA
- Volume
- 28
- Number
- 6
- Start Page
- 357
- End Page
- 361
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86584
- DOI
- 10.1017/neu.2016.25
- ISSN
- 0924-2708
- Abstract
- Background: Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-gamma+ 874 A/T, TNF-alpha-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD. Method: This study enroled 135 PD patients and 135 healthy controls. INF-gamma+874 A/T (rs2430561), TNF-alpha-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped. Results: There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group. Conclusion: We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.