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Factors Associated With Antidepressant Dosing in Asia Findings From the Research on Asian Psychotropic Prescription Study

Authors
Rajaratnam, KaminiXiang, Yu-TaoTripathi, AdarshChiu, Helen Fung KumSi, Tian-MeiChee, Kok-YoonAvasthi, AjitGrover, SandeepChong, Mian-YoonKuga, HironoriKanba, ShigenobuHe, Yan-LingLee, Min-SooYang, Shu-YuUdomratn, PichetKallivayalil, Roy AbrahamTanra, Andi J.Maramis, MargaritaShen, Winston Wu-DienSartorius, NormanKua, Ee-HeokTan, Chay-HoonMahendran, RathiShinfuku, NaotakaSum, Min YiBaldessarini, Ross J.Sim, Kang
Issue Date
12월-2016
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
antidepressant; bipolar; depression; doses; mood stabilizer
Citation
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, v.36, no.6, pp.716 - 719
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
Volume
36
Number
6
Start Page
716
End Page
719
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/86783
DOI
10.1097/JCP.0000000000000591
ISSN
0271-0749
Abstract
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.
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