Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration
- Authors
- Park, Jin-Chul; Bae, Eun-Bin; Kim, Se-Eun; Kim, So-Yun; Choi, Kyung-Hee; Choi, Jae-Won; Bae, Ji-Hyeon; Ryu, Jae-Jun; Huh, Jung-Bo
- Issue Date
- 11월-2016
- Publisher
- MDPI AG
- Keywords
- alloplast; bone substitutes; biphasic calcium phosphate; calcium pyrophosphate; rhBMP-2
- Citation
- MATERIALS, v.9, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- MATERIALS
- Volume
- 9
- Number
- 11
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86936
- DOI
- 10.3390/ma9110954
- ISSN
- 1996-1944
- Abstract
- This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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