Regional cortical thinning of the orbitofrontal cortex in medication-naive female patients with major depressive disorder is not associated with MAOA-uVNTR polymorphism
DC Field | Value | Language |
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dc.contributor.author | Won, Eunsoo | - |
dc.contributor.author | Choi, Sunyoung | - |
dc.contributor.author | Kang, June | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Ham, Byung-Joo | - |
dc.date.accessioned | 2021-09-03T18:54:33Z | - |
dc.date.available | 2021-09-03T18:54:33Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-10-02 | - |
dc.identifier.issn | 1744-859X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87214 | - |
dc.description.abstract | Background: Orbitofrontal cortex alterations have been suggested to underlie the impaired mood regulation in depression. MAOA-uVNTR (monoamine oxidase A-upstream variable number of tandem repeats) polymorphism has been reported to be associated with major depressive disorder by various studies. The influence of MAOA-uVNTR genotype on function and structure of the orbitofrontal cortex has previously been reported. In this study, we investigated the difference in orbitofrontal cortex thickness between medication-naive female patients with major depressive disorder and healthy controls, and the influence of MAOA-uVNTR genotype on orbitofrontal cortex thickness in depression. Methods: Thirty-one patients with major depressive disorder and 43 healthy controls were included. All participants were subjected to T1-weighted structural magnetic resonance imaging and genotyped for MAOA-uVNTR polymorphism. An automated procedure of FreeSurfer was used to analyze difference in orbitofrontal cortex thickness. Results: Patients showed a significantly thinner left orbitofrontal cortex (F-(1,F-71) = 7.941, p = 0.006) and right orbitofrontal cortex (F-(1,F-71) = 17.447, p < 0.001). For the orbitofrontal cortex sub-region analysis, patients showed a significantly thinner left medial orbitofrontal cortex (F-(1,F-71) = 8.117, p = 0.006), right medial orbitofrontal cortex (F-(1,F-71) = 21.795, p < 0.001) and right lateral orbitofrontal cortex (F-(1,F-71) = 9.932, p = 0.002) compared to healthy controls. No significant interaction of diagnosis and MAOA-uVNTR genotype on orbitofrontal cortex thickness was revealed. Conclusions: Our results suggest that structural alterations of the orbitofrontal cortex may be associated with the pathophysiology of major depressive disorder. Future studies with larger sample sizes are needed to detect a possible association between MAOA-uVNTR genotype and orbitofrontal cortex thickness in depression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | HUMAN CEREBRAL-CORTEX | - |
dc.subject | MONOAMINE-OXIDASE-A | - |
dc.subject | VNTR POLYMORPHISM | - |
dc.subject | MOOD DISORDERS | - |
dc.subject | THICKNESS | - |
dc.subject | BRAIN | - |
dc.subject | GENE | - |
dc.subject | MORPHOMETRY | - |
dc.subject | BEHAVIOR | - |
dc.subject | VIOLENCE | - |
dc.title | Regional cortical thinning of the orbitofrontal cortex in medication-naive female patients with major depressive disorder is not associated with MAOA-uVNTR polymorphism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Soo | - |
dc.contributor.affiliatedAuthor | Ham, Byung-Joo | - |
dc.identifier.doi | 10.1186/s12991-016-0116-0 | - |
dc.identifier.scopusid | 2-s2.0-84991214892 | - |
dc.identifier.wosid | 000385306800001 | - |
dc.identifier.bibliographicCitation | ANNALS OF GENERAL PSYCHIATRY, v.15 | - |
dc.relation.isPartOf | ANNALS OF GENERAL PSYCHIATRY | - |
dc.citation.title | ANNALS OF GENERAL PSYCHIATRY | - |
dc.citation.volume | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | HUMAN CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE-A | - |
dc.subject.keywordPlus | VNTR POLYMORPHISM | - |
dc.subject.keywordPlus | MOOD DISORDERS | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MORPHOMETRY | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | VIOLENCE | - |
dc.subject.keywordAuthor | Major depressive disorder | - |
dc.subject.keywordAuthor | Orbitofrontal cortex thickness | - |
dc.subject.keywordAuthor | Monoamine oxidase A-upstream variable number of tandem repeats | - |
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