Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Regional cortical thinning of the orbitofrontal cortex in medication-naive female patients with major depressive disorder is not associated with MAOA-uVNTR polymorphism

Authors
Won, EunsooChoi, SunyoungKang, JuneLee, Min-SooHam, Byung-Joo
Issue Date
2-10월-2016
Publisher
BIOMED CENTRAL LTD
Keywords
Major depressive disorder; Orbitofrontal cortex thickness; Monoamine oxidase A-upstream variable number of tandem repeats
Citation
ANNALS OF GENERAL PSYCHIATRY, v.15
Indexed
SCIE
SSCI
SCOPUS
Journal Title
ANNALS OF GENERAL PSYCHIATRY
Volume
15
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87214
DOI
10.1186/s12991-016-0116-0
ISSN
1744-859X
Abstract
Background: Orbitofrontal cortex alterations have been suggested to underlie the impaired mood regulation in depression. MAOA-uVNTR (monoamine oxidase A-upstream variable number of tandem repeats) polymorphism has been reported to be associated with major depressive disorder by various studies. The influence of MAOA-uVNTR genotype on function and structure of the orbitofrontal cortex has previously been reported. In this study, we investigated the difference in orbitofrontal cortex thickness between medication-naive female patients with major depressive disorder and healthy controls, and the influence of MAOA-uVNTR genotype on orbitofrontal cortex thickness in depression. Methods: Thirty-one patients with major depressive disorder and 43 healthy controls were included. All participants were subjected to T1-weighted structural magnetic resonance imaging and genotyped for MAOA-uVNTR polymorphism. An automated procedure of FreeSurfer was used to analyze difference in orbitofrontal cortex thickness. Results: Patients showed a significantly thinner left orbitofrontal cortex (F-(1,F-71) = 7.941, p = 0.006) and right orbitofrontal cortex (F-(1,F-71) = 17.447, p < 0.001). For the orbitofrontal cortex sub-region analysis, patients showed a significantly thinner left medial orbitofrontal cortex (F-(1,F-71) = 8.117, p = 0.006), right medial orbitofrontal cortex (F-(1,F-71) = 21.795, p < 0.001) and right lateral orbitofrontal cortex (F-(1,F-71) = 9.932, p = 0.002) compared to healthy controls. No significant interaction of diagnosis and MAOA-uVNTR genotype on orbitofrontal cortex thickness was revealed. Conclusions: Our results suggest that structural alterations of the orbitofrontal cortex may be associated with the pathophysiology of major depressive disorder. Future studies with larger sample sizes are needed to detect a possible association between MAOA-uVNTR genotype and orbitofrontal cortex thickness in depression.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Ham, Byung Joo photo

Ham, Byung Joo
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE