Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

The contribution of activated peripheral kappa opioid receptors (kORs) in the inflamed knee joint to anti-nociception

Authors
Moon, Sun WookPark, Eui HoSuh, Hye RimKo, Duk HwanKim, Yang InHan, Hee Chul
Issue Date
1-10월-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Peripheral kappa opioid receptor; U50488; nor-BNI/DIPPA; Carrageenan-induced arthritis; Single nerve recording; Weight-bearing
Citation
BRAIN RESEARCH, v.1648, pp.11 - 18
Indexed
SCIE
SCOPUS
Journal Title
BRAIN RESEARCH
Volume
1648
Start Page
11
End Page
18
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87220
DOI
10.1016/j.brainres.2016.06.048
ISSN
0006-8993
Abstract
The systemic administration of opioids can be used for their strong analgesic effect. However, extensive activation of opioid receptors (ORs) beyond the targeted tissue can cause dysphoria, pruritus, and constipation. Therefore, selective activation of peripheral ORs present in the afferent fibers of the targeted tissue can be considered a superior strategy in opioid analgesia to avoid potential adverse effects. The purpose of this study was to clarify the role of peripheral kappa opioid receptors (kORs) in arthritic pain for the possible use of peripheral ORs as a target in anti-nociceptive therapy. We administered U50488 or nor-BNI/DIPPA, a selective agonist or antagonist of kOR, respectively into arthritic rat knee joints induced using 1% carrageenan. After the injection of U50488 or U50488 with nor-BNI or DIPPA into the inflamed knee joint, we evaluated nociceptive behavior as indicated by reduced weight-bearing on the ipsilateral limbs of the rat and recorded the activity of mechanosensitive afferents (MSA). In the inflamed knee joint, the intra-articular application of 1 mu M, 10 nM, or 0.1 nM U50488 resulted in a significant reduction in nociceptive behavior. In addition, 1 mu M and 10 nM U50488 decreased MSA activity. However, in a non-inflamed knee joint, 1 mu M U50488 had no effect on MSA activity. Additionally, intra-articular pretreatment with 20 mu M nor-BNI or 10 mu M DIPPA significantly blocked the inhibitory effects of 1 mu M U50488 on nociceptive behavior and MSA activity in the inflamed knee joint. These results implicate that peripheral kORs can contribute to anti-nociceptive processing in an inflamed knee joint. (C) 2016 Elsevier B.V. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Han, Hee Chul photo

Han, Hee Chul
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE