Late-acquired incomplete stent apposition after everolimus-eluting stent versus sirolimus-eluting stent implantation in patients with non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction (APPOSITION-AMI)
- Authors
- Hur, Seung-Ho; Lee, Bong-Ryeol; Kim, Sang Wook; Hong, Young Joon; Bae, Jang-Ho; Choi, Donghoon; Kang, Hyun-Jae; Choi, So-Yeon; Lee, Sang Gon; Kim, Doo-Il; Park, Jong-Seon; Rha, Seung Woon
- Issue Date
- Oct-2016
- Publisher
- EUROPA EDITION
- Keywords
- myocardial infarction; stents; ultrasonography
- Citation
- EUROINTERVENTION, v.12, no.8, pp.E979 - E986
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROINTERVENTION
- Volume
- 12
- Number
- 8
- Start Page
- E979
- End Page
- E986
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87313
- DOI
- 10.4244/EIJY15M09_12
- ISSN
- 1774-024X
- Abstract
- Aims: Our aim was to evaluate the incidence and clinical outcomes of late-acquired incomplete stent apposition (LAISA) after implantation of first- and second-generation drug-eluting stents in patients with acute myocardial infarction (AMI). Methods and results: Late-Acquired incomplete stent aPPOsition after everolimus-eluting stent versus sirolimus-eluting Stent ImplanTatION in pAtients with non ST-segment elevation Myocardial Infarction and ST-segment elevation myocardial infarction (APPOSITION-AMI) was a prospective, randomised study comparing LAISA after everolimus-eluting stent (EES) and sirolimus-eluting stent (SES) implantation in AMI patients. Intravascular ultrasound examination was serially performed post-procedurally and at eight-month follow-up in 195 AMI patients (205 native coronary lesions: 100 EES; 105 SES). LAISA was observed in 6.0% and 16.2% of EES- vs. SES-treated lesions (p=0.021), respectively. In 64.7% of SEStreated lesions, LAISA was caused by positive remodelling, whereas thrombus dissolution or plaque reduction was observed in 66.7% of EES-treated lesions. Among patients with LAISA, MACE developed in one (4.5%) in the SES group with no ST in either group up to one year. Conclusions: The incidence of LAISA was lower in AMI patients treated with EES as compared to SES, mainly secondary to positive remodelling in SES- but not EES-treated lesions. Patients with LAISA in both groups showed a very low MACE incidence at one-year follow-up.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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