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Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea
- Authors
- Moon, Hyoung Joon; Oh, Jin Sik; Na, Woonsung; Yeom, Minjoo; Han, Sang Yoon; Kim, Sung Jae; Park, Bong Kyun; Song, Dae Sub; Kang, Bo Kyu
- Issue Date
- Oct-2016
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- Influenza; Pig; Vaccine; H1N1
- Citation
- IMMUNE NETWORK, v.16, no.5, pp.311 - 315
- Indexed
- SCOPUS
KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 16
- Number
- 5
- Start Page
- 311
- End Page
- 315
- ISSN
- 1598-2629
- Abstract
- A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with > 99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
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