Analysis of single nucleotide polymorphism among Varicella-Zoster Virus and identification of vaccine-specific sites
DC Field | Value | Language |
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dc.contributor.author | Jeon, Jeong Seon | - |
dc.contributor.author | Won, Youn Hee | - |
dc.contributor.author | Kim, In Kyo | - |
dc.contributor.author | Ahn, Jin Hyun | - |
dc.contributor.author | Shin, Ok Sarah | - |
dc.contributor.author | Kim, Jung Hwan | - |
dc.contributor.author | Lee, Chan Hee | - |
dc.date.accessioned | 2021-09-03T20:11:39Z | - |
dc.date.available | 2021-09-03T20:11:39Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87559 | - |
dc.description.abstract | Varicella-zoster virus (VZV) is a causative agent for chickenpox and zoster. Live attenuated vaccines have been developed based on Oka and MAV/06 strains. In order to understand the molecular mechanisms of attenuation, complete genome sequences of vaccine and wild-type strains were compared and single nucleotide polymorphism (SNP) was analyzed. ORF22 and ORF62 contained the highest number of SNPs. The detailed analysis of the SNPs suggested 24 potential vaccine-specific sites. All the mutational events found in vaccine-specific sites were transitional, and most of them were substitution of AT to GC pair. Interestingly, 18 of the vaccine-specific sites of the vaccine strains appeared to be genetically heterogeneous. The probability of a single genome of vaccine strain to contain all 24 vaccine-type sequences was calculated to be less than 4%. The average codon adaptation index (CAI) value of the vaccine strains was significantly lower than the CAI value of the clinical strains. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | CODON ADAPTATION INDEX | - |
dc.subject | COMPLETE DNA-SEQUENCES | - |
dc.subject | READING FRAME 62 | - |
dc.subject | TRANSACTIVATION ACTIVITY | - |
dc.subject | GENOME EVOLUTION | - |
dc.subject | PARENTAL VIRUS | - |
dc.subject | OKA VACCINE | - |
dc.subject | STRAIN | - |
dc.subject | RECOMBINATION | - |
dc.subject | PROTEIN | - |
dc.title | Analysis of single nucleotide polymorphism among Varicella-Zoster Virus and identification of vaccine-specific sites | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Ok Sarah | - |
dc.identifier.doi | 10.1016/j.virol.2016.06.017 | - |
dc.identifier.scopusid | 2-s2.0-84976426698 | - |
dc.identifier.wosid | 000381235700030 | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.496, pp.277 - 286 | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 496 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 286 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | CODON ADAPTATION INDEX | - |
dc.subject.keywordPlus | COMPLETE DNA-SEQUENCES | - |
dc.subject.keywordPlus | READING FRAME 62 | - |
dc.subject.keywordPlus | TRANSACTIVATION ACTIVITY | - |
dc.subject.keywordPlus | GENOME EVOLUTION | - |
dc.subject.keywordPlus | PARENTAL VIRUS | - |
dc.subject.keywordPlus | OKA VACCINE | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Varicella-zoster virus (VZV) | - |
dc.subject.keywordAuthor | Live attenuated vaccine | - |
dc.subject.keywordAuthor | Single nucleotide polymorphism (SNP) | - |
dc.subject.keywordAuthor | Vaccine-specific sites | - |
dc.subject.keywordAuthor | Sequence diversity | - |
dc.subject.keywordAuthor | Genetic heterogeneity | - |
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