Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson's Disease
- Authors
- Kwon, Kyum-Yil; Pyo, Seon Jong; Lee, Hye Mi; Seo, Woo-Keun; Koh, Seong-Beom
- Issue Date
- 9월-2016
- Publisher
- KOREAN MOVEMENT DISORDERS SOC
- Keywords
- Parkinson' s disease; blood pressure; heart rate; variability; cognition
- Citation
- JOURNAL OF MOVEMENT DISORDERS, v.9, no.3, pp.144 - 151
- Indexed
- KCI
OTHER
- Journal Title
- JOURNAL OF MOVEMENT DISORDERS
- Volume
- 9
- Number
- 3
- Start Page
- 144
- End Page
- 151
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87595
- DOI
- 10.14802/jmd.16012
- ISSN
- 2005-940X
- Abstract
- Objective We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson's disease (PD). Methods We selected drug-naive PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score <= -2. Results Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP. Conclusion This exploratory study showed that baseline cognition in drug-naive PD patients might be related to the visit-to-visit variability of DBP and/or HR.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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