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Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols
- Issue Date
- 9월-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- aldehydes; alkynyl carboxylic acid; decarboxylative coupling; ketones; propargyl alcohol
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.5, no.9, pp.1148 - 1154
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 5
- Number
- 9
- Start Page
- 1148
- End Page
- 1154
- ISSN
- 2193-5807
- Abstract
- Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.
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