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Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

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dc.contributor.authorJang, Joo Hee-
dc.contributor.authorLee, Hoyeon-
dc.contributor.authorSharma, Amit-
dc.contributor.authorLee, Sang Min-
dc.contributor.authorLee, Tae Hoon-
dc.contributor.authorKang, Chulhun-
dc.contributor.authorKim, Jong Seung-
dc.date.accessioned2021-09-03T21:05:51Z-
dc.date.available2021-09-03T21:05:51Z-
dc.date.created2021-06-18-
dc.date.issued2016-08-18-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/87802-
dc.description.abstractAn indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectDRUG-DELIVERY-
dc.subjectMULTISTAGE TUMORIGENESIS-
dc.subjectPOLYMERIC NANOPARTICLES-
dc.subjectCARCINOMA-CELLS-
dc.subjectCATHEPSIN-L-
dc.subjectTHERAPY-
dc.subjectINHIBITORS-
dc.subjectAPOPTOSIS-
dc.subjectCYCLOOXYGENASE-2-
dc.subjectINFLAMMATION-
dc.titleIndomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Jong Seung-
dc.identifier.doi10.1039/c6cc04255d-
dc.identifier.scopusid2-s2.0-84982693879-
dc.identifier.wosid000382095200025-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.52, no.64, pp.9965 - 9968-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume52-
dc.citation.number64-
dc.citation.startPage9965-
dc.citation.endPage9968-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusMULTISTAGE TUMORIGENESIS-
dc.subject.keywordPlusPOLYMERIC NANOPARTICLES-
dc.subject.keywordPlusCARCINOMA-CELLS-
dc.subject.keywordPlusCATHEPSIN-L-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusCYCLOOXYGENASE-2-
dc.subject.keywordPlusINFLAMMATION-
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