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Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Authors
Jang, Joo HeeLee, HoyeonSharma, AmitLee, Sang MinLee, Tae HoonKang, ChulhunKim, Jong Seung
Issue Date
18-8월-2016
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.52, no.64, pp.9965 - 9968
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
52
Number
64
Start Page
9965
End Page
9968
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87802
DOI
10.1039/c6cc04255d
ISSN
1359-7345
Abstract
An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.
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