Ionic and thermo-switchable polymer-masked mesoporous silica drug-nanocarrier: High drug loading capacity at 10 degrees C and fast drug release completion at 40 degrees C
DC Field | Value | Language |
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dc.contributor.author | Eltohamy, Mohamed | - |
dc.contributor.author | Seo, Jae-Won | - |
dc.contributor.author | Hwang, Ji-Young | - |
dc.contributor.author | Jang, Won-Cheoul | - |
dc.contributor.author | Kim, Hae-Won | - |
dc.contributor.author | Shin, Ueon Sang | - |
dc.date.accessioned | 2021-09-03T21:14:34Z | - |
dc.date.available | 2021-09-03T21:14:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87852 | - |
dc.description.abstract | The preparation of the ideal smart drug-delivery systems were successfully achieved by the in situ co-polymerization of a vinyl group-functionalized mesoporous silica nanoparticle (f-MSN) with 1-butyl-3-vinyl imidazolium bromide (BVIm) and N-isopropylacrylamide (NIPAAm) monomers. The thickness of the capping copolymer layer, poly(NIPAAm-co-BVIm) (p-NIBIm), was controlled at between 2.5 nm and 5 nm, depending on the monomers/f-MSN ratio in the reaction solution. The finally obtained smart drug-delivery systems are named as p-MSN2.5 and p-MSN5.0 (MSNs integrated by 2.5 nm and 5 nm p-NIBIm layer in thickness). The key roles of the mesoporous-silica-nanoparticle (MSN) core and the p-NIBIm shell are drug-carrying (or containing) and pore-capping, respectively, and the latter has an on/off function that operates in accordance with temperature changes. According to the swelling- or shrinking-responses of the smart capping copolymer to temperature changes between 10 degrees C and 40 degrees C, the loading and releasing patterns of the model drug cytochrome c were studied in vitro. The developed system showed interesting performances such as a cytochrome-c-loading profile (loading capacity for 3 h = 26.3% and 19.8% for p-MSN2.5 and p-MSN5.0, respectively) at 10 degrees C and a cytochrome-c-releasing profile (releasing efficiency = > 95% within 3 days and 4days for p-MSN2.5 and p-MSN5.0, respectively) at 40 degrees C. The cytotoxicity of the drug delivery systems, p-MSN2.5 and p-MSN5.0 (in the concentration range of <0.125 mg/mL without drug), for human embryonic kidney (HEK 293) cells were minimal in vitro compared with that of a blank MSN. These results may be reasonably applied in the field of specified drug delivery. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | IN-VIVO | - |
dc.subject | DELIVERY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | STIMULI | - |
dc.subject | COPOLYMER | - |
dc.subject | SYSTEMS | - |
dc.subject | CELLS | - |
dc.subject | LIGHT | - |
dc.subject | LCST | - |
dc.subject | SIZE | - |
dc.title | Ionic and thermo-switchable polymer-masked mesoporous silica drug-nanocarrier: High drug loading capacity at 10 degrees C and fast drug release completion at 40 degrees C | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Ji-Young | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.04.023 | - |
dc.identifier.scopusid | 2-s2.0-84963706296 | - |
dc.identifier.wosid | 000377837200027 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.144, pp.229 - 237 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 144 | - |
dc.citation.startPage | 229 | - |
dc.citation.endPage | 237 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | STIMULI | - |
dc.subject.keywordPlus | COPOLYMER | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | LCST | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordAuthor | Smart drug-delivery system | - |
dc.subject.keywordAuthor | Ionic thermo-sensitive copolymer | - |
dc.subject.keywordAuthor | Mesoporous silica nanoparticle | - |
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