Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Ionic and thermo-switchable polymer-masked mesoporous silica drug-nanocarrier: High drug loading capacity at 10 degrees C and fast drug release completion at 40 degrees C

Authors
Eltohamy, MohamedSeo, Jae-WonHwang, Ji-YoungJang, Won-CheoulKim, Hae-WonShin, Ueon Sang
Issue Date
1-8월-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Smart drug-delivery system; Ionic thermo-sensitive copolymer; Mesoporous silica nanoparticle
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v.144, pp.229 - 237
Indexed
SCIE
SCOPUS
Journal Title
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume
144
Start Page
229
End Page
237
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87852
DOI
10.1016/j.colsurfb.2016.04.023
ISSN
0927-7765
Abstract
The preparation of the ideal smart drug-delivery systems were successfully achieved by the in situ co-polymerization of a vinyl group-functionalized mesoporous silica nanoparticle (f-MSN) with 1-butyl-3-vinyl imidazolium bromide (BVIm) and N-isopropylacrylamide (NIPAAm) monomers. The thickness of the capping copolymer layer, poly(NIPAAm-co-BVIm) (p-NIBIm), was controlled at between 2.5 nm and 5 nm, depending on the monomers/f-MSN ratio in the reaction solution. The finally obtained smart drug-delivery systems are named as p-MSN2.5 and p-MSN5.0 (MSNs integrated by 2.5 nm and 5 nm p-NIBIm layer in thickness). The key roles of the mesoporous-silica-nanoparticle (MSN) core and the p-NIBIm shell are drug-carrying (or containing) and pore-capping, respectively, and the latter has an on/off function that operates in accordance with temperature changes. According to the swelling- or shrinking-responses of the smart capping copolymer to temperature changes between 10 degrees C and 40 degrees C, the loading and releasing patterns of the model drug cytochrome c were studied in vitro. The developed system showed interesting performances such as a cytochrome-c-loading profile (loading capacity for 3 h = 26.3% and 19.8% for p-MSN2.5 and p-MSN5.0, respectively) at 10 degrees C and a cytochrome-c-releasing profile (releasing efficiency = > 95% within 3 days and 4days for p-MSN2.5 and p-MSN5.0, respectively) at 40 degrees C. The cytotoxicity of the drug delivery systems, p-MSN2.5 and p-MSN5.0 (in the concentration range of <0.125 mg/mL without drug), for human embryonic kidney (HEK 293) cells were minimal in vitro compared with that of a blank MSN. These results may be reasonably applied in the field of specified drug delivery. (C) 2016 Elsevier B.V. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE