Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Gi Uk | - |
dc.contributor.author | Park, Il-Hyun | - |
dc.contributor.author | Ahn, Kwangseog | - |
dc.contributor.author | Ahn, Byung-Yoon | - |
dc.date.accessioned | 2021-09-03T21:22:29Z | - |
dc.date.available | 2021-09-03T21:22:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87895 | - |
dc.description.abstract | SAMHD1 is a cellular protein that possesses dNTPase activity and inhibits retroviruses and DNA viruses through the depletion of cellular dNTPs. However, recent evidence suggests the existence of alternative or additional mechanisms that involve novel nuclease activities. Hepatitis B virus is a DNA virus but resembles retroviruses in that its DNA genome is synthesized via reverse transcription of an RNA transcript. SAMHD1 was shown to inhibit the expression and replication of a transfected HBV DNA. We further investigated the antiviral mechanisms in a newly developed infection assay. Our data indicated that SAMHD1 exerts a profound antiviral effect. In addition, unlike previous findings, our results demonstrate the essential role of SAMHD1 dNTPase. SAMHD1 did not affect virion-derived cccDNA and gene expression but specifically inhibited viral DNA synthesis. These results indicate that SAMHD1 inhibits HBV replication at the reverse transcription step, most likely through the depletion of cellular dNTPs. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | HIV-1 RESTRICTION | - |
dc.subject | TRIPHOSPHOHYDROLASE | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INFECTION | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | MACROPHAGES | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | GENE | - |
dc.title | Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Byung-Yoon | - |
dc.identifier.doi | 10.1016/j.virol.2016.05.001 | - |
dc.identifier.scopusid | 2-s2.0-84966429498 | - |
dc.identifier.wosid | 000378659900008 | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.495, pp.71 - 78 | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 495 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 78 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | HIV-1 RESTRICTION | - |
dc.subject.keywordPlus | TRIPHOSPHOHYDROLASE | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | SAMHD1 | - |
dc.subject.keywordAuthor | HBV restriction | - |
dc.subject.keywordAuthor | dNTPase | - |
dc.subject.keywordAuthor | cccDNA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.