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Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1

Authors
Jeong, Gi UkPark, Il-HyunAhn, KwangseogAhn, Byung-Yoon
Issue Date
8월-2016
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
SAMHD1; HBV restriction; dNTPase; cccDNA
Citation
VIROLOGY, v.495, pp.71 - 78
Indexed
SCIE
SCOPUS
Journal Title
VIROLOGY
Volume
495
Start Page
71
End Page
78
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87895
DOI
10.1016/j.virol.2016.05.001
ISSN
0042-6822
Abstract
SAMHD1 is a cellular protein that possesses dNTPase activity and inhibits retroviruses and DNA viruses through the depletion of cellular dNTPs. However, recent evidence suggests the existence of alternative or additional mechanisms that involve novel nuclease activities. Hepatitis B virus is a DNA virus but resembles retroviruses in that its DNA genome is synthesized via reverse transcription of an RNA transcript. SAMHD1 was shown to inhibit the expression and replication of a transfected HBV DNA. We further investigated the antiviral mechanisms in a newly developed infection assay. Our data indicated that SAMHD1 exerts a profound antiviral effect. In addition, unlike previous findings, our results demonstrate the essential role of SAMHD1 dNTPase. SAMHD1 did not affect virion-derived cccDNA and gene expression but specifically inhibited viral DNA synthesis. These results indicate that SAMHD1 inhibits HBV replication at the reverse transcription step, most likely through the depletion of cellular dNTPs. (C) 2016 Elsevier Inc. All rights reserved.
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