Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis
- Authors
- Lee, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 8월-2016
- Publisher
- FUTURE MEDICINE LTD
- Keywords
- FCGR polymorphism; responsiveness; spondyloarthropathy; TNF blockers
- Citation
- PHARMACOGENOMICS, v.17, no.13, pp.1465 - 1477
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOGENOMICS
- Volume
- 17
- Number
- 13
- Start Page
- 1465
- End Page
- 1477
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87896
- DOI
- 10.2217/pgs.16.27
- ISSN
- 1462-2416
- Abstract
- Aim: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-alpha therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Materials & methods: We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to TNF blockers. Results: The meta-analysis indicated that responsiveness to TNF blockers was associated with the FCGR3A V allele (odds ratio: 3.308; 95% CI: 1.053-10.39; p = 0.040) and the FCGR2A RR + RH genotype (odds ratio: 3.904; p = 0.027) in patients with a follow-up time of >= 6 months. Conclusion: FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-alpha therapy in patients with follow-up times >= 6 months.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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