Amelioration of an LPS-induced inflammatory response using a methanolic extract of Lagerstroemia ovalifolia to suppress the activation of NF-B in RAW264.7 macrophages
DC Field | Value | Language |
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dc.contributor.author | Park, Ji-Won | - |
dc.contributor.author | Kwon, Ok-Kyoung | - |
dc.contributor.author | Yuniato, Prasetyawan | - |
dc.contributor.author | Marwoto, Bambang | - |
dc.contributor.author | Lee, Joongku | - |
dc.contributor.author | Oh, Sei-Ryang | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.contributor.author | Ahn, Kyung-Seop | - |
dc.date.accessioned | 2021-09-03T21:25:55Z | - |
dc.date.available | 2021-09-03T21:25:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87918 | - |
dc.description.abstract | Lagerstroemia ovalifolia Teijsm. & Binn. has traditionally been used as an herbal medicine and possesses anti-inflammatory properties. However, the mechanisms underlying its anti-inflammatory effects remain poorly understood. For this purpose, we aimed to investigate the effects of methanolic extract of L. ovalifolia (LOME) on nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production, as well as the underlying molecular mechanisms responsible for these effects, in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. We examined the effects of LOME on the production of NO and PGE(2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of LOME, we measured the mRNA or protein expression of the pro-inflammatory mediators induced by LOME in the LPS-stimulated RAW264.7 cells. LOME significantly inhibited the production of NO, PGE(2), interleukin (IL)-6, IL-1, and tumor necrosis factor- (TNF-) in LPS-stimulated RAW264.7 cells. Moreover, LOME suppressed the mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and inhibited the phosphorylation of the mitogen-activated protein kinases (MAPKs), with a reduction in the nuclear translocation of nuclear factor (NF)-B in LPS-stimulated RAW264.7 cells. Taken together, these findings suggest that LOME may exert anti-inflammatory effects in vitro in LPS-stimulated RAW264.7 macrophages and thus, may have potential for use as an adjuvant treatment of inflammatory diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | KAPPA-B | - |
dc.subject | NLRP3 INFLAMMASOME | - |
dc.subject | COX-2 EXPRESSION | - |
dc.subject | INHIBITS INOS | - |
dc.subject | PROSTAGLANDINS | - |
dc.subject | LYTHRACEAE | - |
dc.subject | MEDIATORS | - |
dc.subject | APOPTOSIS | - |
dc.title | Amelioration of an LPS-induced inflammatory response using a methanolic extract of Lagerstroemia ovalifolia to suppress the activation of NF-B in RAW264.7 macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.3892/ijmm.2016.2646 | - |
dc.identifier.scopusid | 2-s2.0-84978863814 | - |
dc.identifier.wosid | 000381288800013 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.38, no.2, pp.482 - 490 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 482 | - |
dc.citation.endPage | 490 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | INHIBITS INOS | - |
dc.subject.keywordPlus | PROSTAGLANDINS | - |
dc.subject.keywordPlus | LYTHRACEAE | - |
dc.subject.keywordPlus | MEDIATORS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Lagerstroemia ovalifolia Teijsm | - |
dc.subject.keywordAuthor | & | - |
dc.subject.keywordAuthor | Binn | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | MARK | - |
dc.subject.keywordAuthor | NF-B | - |
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