Disassembly of Chromophore-Guided DNA Duplexes through Site-Selective Binding of Coralyne to Pyrene-Modified Adenine Bases
- Authors
- Kim, Ki Tae; Choi, Tae Su; Kim, Ka Young; Kim, Hugh I.; Kim, Byeang Hyean
- Issue Date
- 7월-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- coralyne; DNA disassembly; intercalations; molecular devices; polydeoxyadenylates
- Citation
- CHEMPLUSCHEM, v.81, no.7, pp.590 - 593
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMPLUSCHEM
- Volume
- 81
- Number
- 7
- Start Page
- 590
- End Page
- 593
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88179
- DOI
- 10.1002/cplu.201600230
- ISSN
- 2192-6506
- Abstract
- Under ambient conditions the disassembly of self-duplexes of (Py)A-modified oligodeoxyadenylates (i.e., chromophore-guided DNA assemblies) through intercalative binding of coralyne units to pyrene-modified adenine ((Py)A) bases was carried out. The coralyne units, intercalated site-selectively on the 3 sides of the (Py)A units, are stabilized through - stacking interactions. This competitive intercalation destabilizes the stacking interactions of pairs of (Py)A units, resulting in dissociation of the self-duplexes. This behavior, which is opposite to that of coralyne-induced self-duplex formation of natural oligodeoxyadenylates, was exploited to prepare new types of DNA modules that can be switched between two different duplex states.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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