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A fluorescent probe for the Fe3+ ion pool in endoplasmic reticulum in liver cells
- Issue Date
- 7월-2016
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Iron detection; Fluorescent probe; Rhodamine; Cell imaging
- Citation
- DYES AND PIGMENTS, v.130, pp.245 - 250
- Indexed
- SCIE
SCOPUS
- Journal Title
- DYES AND PIGMENTS
- Volume
- 130
- Start Page
- 245
- End Page
- 250
- ISSN
- 0143-7208
- Abstract
- We have presented rhodamine-derived Schiff base probes (1-6) selective of the Fe3+ ion in biological systems. In the presence of Fe3+ ions, the probes display new absorption and emission bands at 526 nm and 551 nm, respectively. Confocal microscopic analysis using the HepG2 cell line showed that probes 1-6 provide fluorescence Off-On changes caused by cellular Fe3+ ions, and demonstrated a largely enhanced fluorescence upon iron overloading of the cells. We also found that the Fe3+ ion-mediated fluorescence changes of probes 1-6 are mainly localized in the ER (Endoplasmic Reticulum) in HepG2 cells. Among them, probe 5 exhibits the highest selectivity for ER localization over the other organelles. (C) 2016 Elsevier Ltd. All rights reserved.
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