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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

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dc.contributor.authorSong, No-Joon-
dc.contributor.authorChoi, Seri-
dc.contributor.authorRajbhandari, Prashant-
dc.contributor.authorChang, Seo-Hyuk-
dc.contributor.authorKim, Suji-
dc.contributor.authorVergnes, Laurent-
dc.contributor.authorKwon, So-Mi-
dc.contributor.authorYoon, Jung-Hoon-
dc.contributor.authorLee, Sukchan-
dc.contributor.authorKu, Jin-Mo-
dc.contributor.authorLee, Jeong-Soo-
dc.contributor.authorReue, Karen-
dc.contributor.authorKoo, Seung-Hoi-
dc.contributor.authorTontonoz, Peter-
dc.contributor.authorPark, Kye Won-
dc.date.accessioned2021-09-03T22:33:45Z-
dc.date.available2021-09-03T22:33:45Z-
dc.date.created2021-06-18-
dc.date.issued2016-07-
dc.identifier.issn1552-4450-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/88272-
dc.description.abstractIncreasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4 dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectFAT DEVELOPMENT-
dc.subjectADIPOCYTES-
dc.subjectOBESITY-
dc.subjectTHERMOGENESIS-
dc.subjectEXPRESSION-
dc.subjectABLATION-
dc.subjectMOUSE-
dc.subjectCELL-
dc.titlePrdm4 induction by the small molecule butein promotes white adipose tissue browning-
dc.typeArticle-
dc.contributor.affiliatedAuthorKoo, Seung-Hoi-
dc.identifier.doi10.1038/NCHEMBIO.2081-
dc.identifier.scopusid2-s2.0-84966621800-
dc.identifier.wosid000378087500005-
dc.identifier.bibliographicCitationNATURE CHEMICAL BIOLOGY, v.12, no.7, pp.479 - +-
dc.relation.isPartOfNATURE CHEMICAL BIOLOGY-
dc.citation.titleNATURE CHEMICAL BIOLOGY-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPage479-
dc.citation.endPage+-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.subject.keywordPlusFAT DEVELOPMENT-
dc.subject.keywordPlusADIPOCYTES-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusTHERMOGENESIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusABLATION-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusCELL-
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