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Prdm4 induction by the small molecule butein promotes white adipose tissue browning
- Authors
- Song, No-Joon; Choi, Seri; Rajbhandari, Prashant; Chang, Seo-Hyuk; Kim, Suji; Vergnes, Laurent; Kwon, So-Mi; Yoon, Jung-Hoon; Lee, Sukchan; Ku, Jin-Mo; Lee, Jeong-Soo; Reue, Karen; Koo, Seung-Hoi; Tontonoz, Peter; Park, Kye Won
- Issue Date
- 7월-2016
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE CHEMICAL BIOLOGY, v.12, no.7, pp.479 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE CHEMICAL BIOLOGY
- Volume
- 12
- Number
- 7
- Start Page
- 479
- End Page
- +
- ISSN
- 1552-4450
- Abstract
- Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4 dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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