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Developing imidazoles as CEST MRI pH sensors
- Authors
- Yang, Xing; Song, Xiaolei; Banerjee, Sangeeta Ray; Li, Yuguo; Byun, Youngjoo; Liu, Guanshu; Bhujwalla, Zaver M.; Pomper, Martin G.; McMahon, Michael T.
- Issue Date
- 7월-2016
- Publisher
- WILEY-HINDAWI
- Keywords
- chemical exchange saturation transfer; imidazole-4,5-dicarboxamides; molecular imaging; pH imaging
- Citation
- CONTRAST MEDIA & MOLECULAR IMAGING, v.11, no.4, pp.304 - 312
- Indexed
- SCIE
SCOPUS
- Journal Title
- CONTRAST MEDIA & MOLECULAR IMAGING
- Volume
- 11
- Number
- 4
- Start Page
- 304
- End Page
- 312
- ISSN
- 1555-4309
- Abstract
- A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright (C) 2016 John Wiley & Sons, Ltd.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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