One for Many: A Universal Reagent for Acylation Processes
- Authors
- Moon, Hyun Kyung; Sung, Gi Hyeon; Kim, Bo Ram; Park, Jong Keun; Yoon, Yong-Jin; Yoon, Hyo Jae
- Issue Date
- 2-6월-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- 2-alkoxycarbonylpyridazin-3(2H)-ones; acylating agents; coupling reactions; heterocycles; mixed carbonic anhydrides
- Citation
- ADVANCED SYNTHESIS & CATALYSIS, v.358, no.11, pp.1725 - 1730
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED SYNTHESIS & CATALYSIS
- Volume
- 358
- Number
- 11
- Start Page
- 1725
- End Page
- 1730
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88371
- DOI
- 10.1002/adsc.201501177
- ISSN
- 1615-4150
- Abstract
- This work describes acylation reactions facilitated by a type of heterocycle-based acyl transfer agent, 2-acyloxypyridazinone. Reactions of 2-acyloxypyridazinone with carboxylic acids yield mixed carbonic anhydride intermediates, which are reactive and could be coupled with a wide range of substrates including acids, amines, alcohols, and thiols. The wide substrate scope, ease of operation (no additive or catalyst), storage and handling stability, and atom-efficiency from recycling the heterocycle carrier make the reported acylating agent attractive for acylation-based coupling reactions.
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