Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Bong | - |
dc.contributor.author | Ahn, Su Bi | - |
dc.contributor.author | Lee, Sang-Woo | - |
dc.contributor.author | Jeong, Shin Young | - |
dc.contributor.author | Ghilsuk, Yoon | - |
dc.contributor.author | Ahn, Byeong-Cheol | - |
dc.contributor.author | Kim, Eun-Mi | - |
dc.contributor.author | Jeong, Hwan-Jeong | - |
dc.contributor.author | Lee, Jaetae | - |
dc.contributor.author | Lim, Dong-Kwon | - |
dc.contributor.author | Jeon, Yong Hyun | - |
dc.date.accessioned | 2021-09-03T23:14:56Z | - |
dc.date.available | 2021-09-03T23:14:56Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1884-4049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88440 | - |
dc.description.abstract | Radionuclide-embedded gold nanoparticles (RIe-AuNPs) were developed as a highly sensitive and stable nuclear and optical imaging agent for efficient dendritic cell (DC)-based immunotherapy and sensitive tracking of DC-migration to lymph nodes. The RIe-AuNPs were synthesized via simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radiosensitivity and excellent in vivo stability. The RIe-AuNPs exert no adverse effects on the biological functions of DCs, and labeled DCs show strong antitumor immunity for lung cancer. Furthermore, the high radiosensitivity of the RIe-AuNPs allows for sensitive and long-term monitoring of DC migration to draining lymph nodes. The developed Cerenkov radiation-based optical imaging approach provides quantitative and sensitive results comparable with that of positron emission tomography imaging. These results highlight the strong potential of the RIe-AuNPs as a highly sensitive and stable nuclear and optical imaging platform for future bioimaging application such as cell tracking and tumor imaging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | LYMPH-NODES | - |
dc.subject | BONE-MARROW | - |
dc.subject | STEM-CELLS | - |
dc.subject | MIGRATION | - |
dc.subject | TRAFFICKING | - |
dc.subject | MELANOMA | - |
dc.subject | THERAPY | - |
dc.subject | PROBES | - |
dc.subject | MOUSE | - |
dc.title | Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong-Kwon | - |
dc.identifier.doi | 10.1038/am.2016.80 | - |
dc.identifier.scopusid | 2-s2.0-85051967577 | - |
dc.identifier.wosid | 000379759800007 | - |
dc.identifier.bibliographicCitation | NPG ASIA MATERIALS, v.8 | - |
dc.relation.isPartOf | NPG ASIA MATERIALS | - |
dc.citation.title | NPG ASIA MATERIALS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | LYMPH-NODES | - |
dc.subject.keywordPlus | BONE-MARROW | - |
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