Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence
- Authors
- Lee, Sang Bong; Ahn, Su Bi; Lee, Sang-Woo; Jeong, Shin Young; Ghilsuk, Yoon; Ahn, Byeong-Cheol; Kim, Eun-Mi; Jeong, Hwan-Jeong; Lee, Jaetae; Lim, Dong-Kwon; Jeon, Yong Hyun
- Issue Date
- 6월-2016
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NPG ASIA MATERIALS, v.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- NPG ASIA MATERIALS
- Volume
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88440
- DOI
- 10.1038/am.2016.80
- ISSN
- 1884-4049
- Abstract
- Radionuclide-embedded gold nanoparticles (RIe-AuNPs) were developed as a highly sensitive and stable nuclear and optical imaging agent for efficient dendritic cell (DC)-based immunotherapy and sensitive tracking of DC-migration to lymph nodes. The RIe-AuNPs were synthesized via simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radiosensitivity and excellent in vivo stability. The RIe-AuNPs exert no adverse effects on the biological functions of DCs, and labeled DCs show strong antitumor immunity for lung cancer. Furthermore, the high radiosensitivity of the RIe-AuNPs allows for sensitive and long-term monitoring of DC migration to draining lymph nodes. The developed Cerenkov radiation-based optical imaging approach provides quantitative and sensitive results comparable with that of positron emission tomography imaging. These results highlight the strong potential of the RIe-AuNPs as a highly sensitive and stable nuclear and optical imaging platform for future bioimaging application such as cell tracking and tumor imaging.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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